What is Betaine Anhydrous (TMG)?

Betaine anhydrous, commonly known as trimethylglycine (TMG), is a vital compound naturally present in foods like beets, spinach, quinoa, and shellfish. It acts as a key methyl donor and osmolyte in the body, playing crucial roles in processes like methylation (essential for numerous metabolic functions) and osmoregulation (maintaining cell hydration and integrity). Growing research highlights its potential to enhance athletic output and protect liver health, making it increasingly popular.
Power Up Your Performance: How Betaine Helps Athletes
Evidence suggests betaine anhydrous supplementation can significantly boost athletic performance. It's thought to work by supporting the body's own creatine production, improving cellular hydration (acting as an osmolyte), and potentially enhancing blood flow. These mechanisms can contribute to increased muscle power, strength, endurance, and potentially improved body composition over time.
Imagine a weightlifter squeezing out an extra rep on their final heavy set, or a runner feeling more sustained energy during the last mile. These are potential real-world effects linked to betaine's impact on energy production and cellular function during demanding exercise.
Protect Your Liver: Betaine's Role in Fat Metabolism
Betaine is a cornerstone for liver health, primarily through its function as a methyl donor. This role is vital for converting homocysteine (an amino acid that can be harmful at high levels) back to methionine. This process supports detoxification pathways and is crucial for fat metabolism within the liver. Betaine helps prevent or reduce the buildup of fat (steatosis), a key factor in non-alcoholic fatty liver disease (NAFLD), thereby supporting overall liver function and health.
Using Betaine Safely: Dosage & Considerations
Betaine anhydrous is generally well-tolerated when used appropriately. Common dosages for performance and health benefits range from 1.5 to 3 grams daily, often split into two doses (e.g., 1.25g twice daily). It's wise to start with a lower dose to assess tolerance. Minor digestive upset (like nausea or mild diarrhea) can occur in some individuals. Always consult your doctor before beginning any new supplement, especially if you have underlying health conditions or take other medications.
Potential Side Effects
- Mild nausea
- Stomach discomfort or cramps
- Diarrhea (less common, often dose-related)
- Temporary fishy body odor (due to trimethylamine metabolism, sometimes occurs at higher doses)
How to Add Betaine to Your Routine

Betaine anhydrous typically comes as a powder or in capsules. Powder can be mixed easily with water, juice, or pre-workout drinks (it has a mildly sweet or slightly bitter taste depending on the source). Capsules offer convenience. Choose products from reputable manufacturers that undergo third-party testing for purity and quality. Consistency is key, whether taking it daily for general health or timed around workouts for performance benefits.
Further Research and Reputable Resources
The understanding of betaine's full potential is still evolving. Ongoing research continues to unveil its nuances. To stay informed, consult peer-reviewed scientific literature and trusted health databases for the latest findings and evidence-based recommendations.