What is Phosphatidylserine (PS)?

Phosphatidylserine (PS) is an essential phospholipid, a type of fat molecule, that is a fundamental component of cell membranes throughout the body, with particularly high concentrations in the brain. It's critical for maintaining the integrity and fluidity of brain cell membranes, which is vital for effective nerve cell (neuron) communication. PS participates actively in crucial cognitive processes like memory formation, learning, attention, and problem-solving. Our body's natural production of PS tends to decrease with age, a factor sometimes linked to age-associated cognitive changes.
How Does Phosphatidylserine Support Brain Function?
PS contributes to brain health in several ways. It helps maintain the necessary fluidity of neuronal membranes, allowing signals to pass efficiently between cells – much like oil keeps gears running smoothly. PS also supports the production and release of key neurotransmitters like acetylcholine (vital for memory and learning) and dopamine (involved in focus, motivation, and mood). Furthermore, PS plays a role in managing the brain's stress response by helping to regulate cortisol levels, promoting resilience. By facilitating these processes, PS supports optimal cognitive function.
Key Cognitive Benefits Linked to Phosphatidylserine

- Supports Memory and Learning: Studies suggest that PS supplementation may help enhance aspects of memory, including recall and recognition, making it easier to learn and retain information.
- Promotes Focus and Attention: PS may contribute to improved concentration and attention span, potentially reducing distractibility and aiding focus during tasks.
- Aids Healthy Brain Aging: Research indicates PS might help mitigate certain aspects of age-related cognitive decline, supporting brain function as we get older.
- Assists Mood Regulation and Stress Management: By potentially helping modulate cortisol (the stress hormone), PS may support a balanced mood and improved stress resilience, indirectly benefiting cognitive clarity.
Phosphatidylserine and Age-Related Cognitive Changes

As natural PS levels decline with age, supplementation has become an area of interest as a supportive strategy for cognitive health. Some clinical trials involving older adults experiencing age-related memory concerns have shown that PS supplementation was associated with improvements in memory and cognitive tasks compared to placebo after several months of use. While not a cure, it represents a potential tool for supporting brain function during aging.
Dosage Recommendations and Safety
Common dosages for phosphatidylserine typically range from 100 mg to 300 mg per day, often split into two or three doses. PS is generally considered safe for most adults when used at recommended levels. However, it is crucial to consult with a qualified healthcare professional before beginning any new supplement regimen. This is especially important if you have underlying health conditions, are pregnant or breastfeeding, or are taking other medications (like blood thinners). Potential side effects are usually mild and infrequent but can include insomnia or stomach upset.
Integrating Phosphatidylserine Effectively
While small amounts of PS are found in foods like soy lecithin, white beans, egg yolks, and organ meats, supplements offer a more concentrated dose. PS supplements are readily available in capsule or softgel form. Consistency is key; taking PS regularly, potentially at the same time each day, may enhance its potential benefits. Remember, PS works best as part of a holistic approach to brain health that includes a balanced diet, regular physical activity, sufficient sleep, and ongoing mental engagement.